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Monday, May 1st   1 PM 5 PM

High Performance Computing in Computational Biology

Horst D. Simon & Sylvia Spengler
Center for Bioinformatics and Computational Genomics 

Manfred Zorn
NERSC at Lawrence Berkeley National Laboratory

Anyone interested in learning about the exciting new developments in bioinformatics, computational biology, and genomics. The tutorial will begin with an introduction of relevant biology concepts and lead into the uses and high performance computing challenges that they present.

The pace of extraordinary advances in molecular biology has accelerated in the past decade due in large part to discoveries coming from genome projects on human and model organisms. The advances in the genome project so far, happening well ahead of schedule and under budget, have exceeded any dreams by its protagonists, let alone formal expectations. Biologists expect the next phase of the genome project to be even more startling in terms of dramatic breakthroughs in our understanding of human biology and the biology of health and disease.

Only today can biologists begin to envision the necessary experimental, computational and theoretical steps necessary to exploit genome sequence information for its medical impact, its contribution to biotechnology and economic competitiveness, and its ultimate contribution to environmental quality. High performance computing has become one of the critical enabling technologies, which will help to translate this vision of future advances in biology into reality.

Biologists are increasingly becoming aware of the potential of high performance computing. The goal of this tutorial is to introduce the exciting new developments in computational biology and genomics to the high performance computing community.

Dr. Manfred D. Zorn is the co-Director of the Center for Bioinformatics and Computational Genomics, jointly with Sylvia J. Spengler and Co-PI on the High-throughput Genome Annotation project, a multi-laboratory effort to annotate the human and other genome sequences generated by Genome Centers world-wide and provide biologists integrated access to this valuable information. Dr. Zorn holds a Master's degree in Chemistry (1986) and a D.Sc. in Biochemistry/Molecular Biology (1989) from the University of Vienna, Austria. He joined the Computing Sciences Division at Lawrence Berkeley Laboratory in 1989 to handle data management and software development efforts at the newly formed Human Genome Center.

Dr. Sylvia J. Spengler is Co-Director, Center for Bioinformatics and Computational Genomics and the director of the DOE Human Genome Program Field Operations. She has been the co-director of the program in Mathematics and Molecular Biology at the University of California at Berkeley. She has an A.B. in Physics and a Ph.D. in Biophysics from the University of California, Berkeley.

Dr. Horst D. Simon is Director of the NERSC (National Energy Research Scientific Computing) Division located at Lawrence Berkeley National Laboratory in Berkeley, CA. NERSC is the principal supplier of production high-performance computing services to the nationwide energy research community. Previously, from 1994 - 1996, Simon was with the Advanced System Division of Silicon Graphics in Mountain View, California, where he managed SGI's university and research laboratory programs. From 1987 - 1994 he was with Computer Sciences Corporation at the NAS Division at NASA Ames Research Center, Moffett Field, California, leading a research department with groups in parallel applications, scientific visualization, and numerical grid generation.


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